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1277 Results
Background INSTIs are known to induce weight/fat gain, the pathogenesis and reversibility of which remain unclear. The ongoing ADDORE study aimed to evaluate the evolution of adipose tissue (AT) between baseline and W48 in PWH with INSTI-associated weight gain switched to TDF/3TC/DOR. We present here preliminary adipocyte gene expression results. Methods PWH underwent two surgical…
Background The glucagon-like peptide-1 receptor agonist semaglutide (SEMA) reduces weight and inflammation in the general population. We previously reported reductions in weight (mean -7.8 kg, 95% confidence interval, [CI, -9.5, -6.1]), insulin resistance (IR), serum triglycerides and liver fat in people with HIV (PWH) receiving SEMA in ACTG A5371, the SLIM LIVER study. Here we…
Background We have previously shown lower life expectancy among females with HIV in British Columbia (BC), Canada, compared to males and an increasing sex gap in life expectancy from 1996 to 2020 (CROI 2024, Abstract #1053). To better understand the underlying drivers for this finding, we aimed to establish whether female sex is associated with…
Background Chronic inflammation is a critical driver of morbidities and mortality in normal aging. In people with HIV (PWH), inflammation can lead to increased incidence and earlier onset of non-AIDS comorbidities and aging syndromes, such as frailty. Here, we measured plasma markers of inflammation and T cell phenotypes from PWH with and without frailty to…
Background Women with HIV (WWH) are at increased risk for developing diabetes mellitus (DM) compared to women without HIV (WWOH). In WWOH, the transition to menopause is associated with metabolic changes that increase DM risk. Whether HIV and menopause are associated with faster increases in insulin resistance, and whether switching to an integrase strand transfer…
Background The associations among inflammatory markers and prevalent or incident frailty, cognitive impairment (CI), clinical events and all-cause mortality in older people with HIV are poorly understood. Methods Participants from the HAILO study ≥50 years were included. Frailty was evaluated using the Fried Frailty assessment (4-meter walk speed, grip strength, unintentional weight loss, exhaustion, low…
Background We previously demonstrated in a 3T3L1cells in vitro model of adipogenesis, that Integrase Strand Transfer Inhibitors (INSTI) increase adipogenesis, while, tenofovir alafenamide fumarate (TAF) and tenofovir disoproxil fumarate (TDF), displayed an inhibitory effect, counteracting increased adipogenesis caused by INSTIs [dolutegravir (DTG), bictegravir (BIC)]. Deregulation of the expression levels of two families of adipocyte differentiation transcription factors, the CCAAT/enhancer-binding proteins (C/EBPs) and the…
Background While novel antidiabetic medications like glucagon like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose co-transporter 2 inhibitors (SGLT2is) have demonstrated weight loss in the general population, data on their impact on weight loss in PWH remains limited. Methods We identified adult PWH in the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) cohort who…
Background Obstructive sleep apnea and diabetes are common among people with HIV (PWH). Cardinal features of obstructive sleep apnea such as intermittent hypoxia and sleep fragmentation have been associated with the development of diabetes in the general population. Among PWH, HIV-associated inflammation and the use of certain ART medications have also been associated with the…
Background Hearing loss (HL) and age-associated dementia (AAD) are prevalent and have considerable detrimental effects on quality of life; HL is a leading preventable risk factor for dementia worldwide. As persons with HIV (PWH) age, they are at particular risk for sensorineural HL and AAD. We used simulation modeling to estimate the prevalences of HL…