Abstracts from 2014 through the most recent CROI can be viewed in this searchable database once they have been presented at the conference. Abstract Contents: The searchable database includes abstract text as submitted by the authors prior to CROI. Study data might be updated during the presentation at CROI. Please refer to the electronic poster or webcast for updates. Searching the Abstract Database: Enter the criteria below and click the “Search” button. After the search has been entered, the results will appear below the search form.
CROI conference materials (eg, the conference program, Abstract eBook, electronic posters, CROI logo, etc) are protected by copyright. Permission to replicate or reproduce these elements, in whole or in part, must be obtained from the CROI Conference Manager, the International Antiviral Society-USA (IAS-USA). Study data (including figures within abstracts or electronic posters) are the property of the study authors. Permission to use data and figures cannot be given by IAS–USA unless it is for regulatory reasons. For more information, please email CROIabstracts@iasusa.org.
1277 Results
Background Single cohort UK data suggests an increased lifetime prevalence of psychosis in young people living with perinatally acquired HIV (YPaHIV) compared to age matched peers in the general population (0.5-1.0%), echoed by US data. This is thought to be due to lifelong exposure to a neurotropic virus, neuroinflammation during brain development, and greater experience…
Background Early ART within 3 months of birth has dramatically improved long-term outcomes in children living with perinatal HIV. However, these children face decades of HIV-associated immune dysregulation and chronic inflammation. Neither the long-term inflammatory profile nor the risk of long-term non-communicable diseases are well understood. We assessed biomarkers associated with inflammation (monocyte and lymphocyte), metabolic and…
Background Perinatal HIV transmission has not meaningfully declined in Kenya since 2015. VL monitoring can both reinforce good adherence and enable timely intervention if viremia is detected early. However, in routine care in Kenya, time from sample collection to results to patients is often weeks when VL is detected and months when suppressed. We assessed…
Background There are few insights into the immunological predictors of pregnancy outcomes, including preterm delivery (PTD) and small-for-gestational age (SGA), in women living with HIV (WLH). Methods We followed ART-eligible pregnant WLH attending primary care in Cape Town from their first antenatal visit through to delivery. C-reactive protein (CRP), interferon gamma-induced protein 10 (IP10), and…
Background People living with HIV (PLWH) receiving contemporary treatment may have increased risk for low birth weight (LBW) or preterm birth (PTB). We hypothesized that LBW and PTB rates among PLWH in an HIV Pregnancy cohort (HP) would not differ from Washington State (WA) birth registry data. We also evaluated perinatal HIV-1 transmission among births…
Background The number of HIV-1-exposed uninfected (HEU) children remains on the rise. Studies showed that HEU children are at increased risk for preterm delivery, infectious morbidity, immune abnormalities, and impaired growth; yet there are gaps in understanding of how in utero HIV-1 and antiretroviral drug (ARVs) exposures may impact HEU children’s health across their lifespan.…
Background Dolutegravir (DTG) is a preferred antiretroviral drug (ARV) as a part of first-line regimen for treatment of people living with human immunodeficiency virus type one (HIV-1). This includes pregnant women or those of reproductive age. Recommended DTG usage, worldwide, is linked to the drug’s potency, high genetic barrier to resistance, limited drug-drug interactions, and cost-effectiveness.…
Background Sexually transmitted infections (STIs) in pregnancy contribute to adverse birth outcomes and increased HIV acquisition during pregnancy and the postpartum period. Yet, few studies evaluate how STI testing influences HIV PrEP use among pregnant women who initiate HIV PrEP. Methods We analyzed data from a randomized trial conducted between February 2022-July 2023 among pregnant…
Background Experiences of childhood physical and sexual assault are prevalent in people living with HIV, yet relationships to antepartum and postpartum viral load (VL) are understudied. We evaluated the relationship of childhood physical or sexual assault (CPA/CSA) to VL during pregnancy and postpartum among participants in the Women’s Health Supplement to the Surveillance Monitoring for…
Background The health of uninfected children exposed to HIV requires long-term assessment, in particular, in terms of neurological and cognitive development. Numerous confounding factors have hampered such assessment, and the data are contradictory. Methods Using data from the French National Health Data System from 2012 to 2022, we conducted a population-based matched cohort study on…