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1277 Results
Background The gut virome is seeded at birth, rapidly develops in the first years of life, and is influenced by numerous behavioral and environmental factors including exposure to the maternal virome. Thus, maternal HIV infection could alter virome development and may contribute to the increased morbidity and mortality seen in children exposed to HIV. However,…
Background Adolescents and young adults living with HIV (ALHIV) face multifaceted challenges to long-term treatment success. We characterized HIV status disclosure among ALHIV and assessed relationships between status disclosure, antiretroviral therapy (ART) adherence and viral suppression. Methods The prospective African Cohort Study enrolls people with and without HIV, ≥15 years, at 12 PEPFAR-supported facilities in Kenya,…
Background Sexually transmitted infections (STIs) in pregnancy contribute to adverse birth outcomes and increased HIV acquisition during pregnancy and the postpartum period. Yet, few studies evaluate how STI testing influences HIV PrEP use among pregnant women who initiate HIV PrEP. Methods We analyzed data from a randomized trial conducted between February 2022-July 2023 among pregnant…
Background Experiences of childhood physical and sexual assault are prevalent in people living with HIV, yet relationships to antepartum and postpartum viral load (VL) are understudied. We evaluated the relationship of childhood physical or sexual assault (CPA/CSA) to VL during pregnancy and postpartum among participants in the Women’s Health Supplement to the Surveillance Monitoring for…
Background The health of uninfected children exposed to HIV requires long-term assessment, in particular, in terms of neurological and cognitive development. Numerous confounding factors have hampered such assessment, and the data are contradictory. Methods Using data from the French National Health Data System from 2012 to 2022, we conducted a population-based matched cohort study on…
Background Women vs men with HIV have a higher burden of aging-related multimorbidity, which may be related to reproductive transitions including pregnancy history. Methods We evaluated longitudinal data collected from women with and without HIV (WWH; WWoH) enrolled in the Women’s Interagency HIV Study and in follow-up on/after 2009 (when >80% of WWH consistently used…
Background Women who acquire HIV during pregnancy are at increased risk for vertical HIV transmission. Major intervention efforts have sought to rapidly reduce HIV incidence in Botswana over the past decade. The Tsepamo Study captures data on ~70% of all deliveries in Botswana including HIV test dates and results during antenatal care. We assessed whether HIV…
Background Despite universal test and treat for HIV, vertical transmission continues to occur. We evaluated the temporal effectiveness of vertical transmission prevention (VTP) over three maternal antiretroviral treatment (ART) policy periods (1. three-drug ART accessible to those with CD4 counts <200 cells/µl; 2. <350 cells/µl; 3. universal ART) in Western Cape, South Africa using routine…
Background Pregnant adolescents and young adults living with HIV (AYALWH) in low-middle-income countries (LMIC), where the transition from HIV to antenatal care (ANC) is required, have poor clinic attendance and retention in HIV care. Little is known about the impact of this pregnancy-associated transition (PAT). This sub-study of the Adapt for Adolescents (A4A) trial evaluates…
Background Adherence to anti-retroviral therapy (ART) is essential for HIV management, and self-efficacy (i.e., one’s confidence in adhering to their medication regimen) correlates to adherence and viral load (VL) suppression. We developed ASES-Chichewa, a 10-item adherence self-efficacy scale (ASES) for Malawi, where lifelong ART is provided to pregnant/breastfeeding women living with HIV to reduce vertical…