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1277 Results
Background HIV infection and substance use have been associated with accelerated epigenetic aging. However, limited data exist on the long-term implications associated with age acceleration and HIV among persons who inject drugs (PWID). Methods We included participants from the AIDS Linked to the Intravenous Experience (ALIVE) study, a community-based cohort of PWID. DNA was isolated…
Background COVID-19 pandemic decreased accessibility to health services in chronic diseases as HIV, with disruption of the continuum of HIV care. In addition, COVID-19 added more death during first waves before immunization, but in PLWH in ART knowledge about impact in the mortality was poor in studies in follow-up. Methods Retrospective study from clinical records…
Background Household couples represent a population wherein there is a clear unit to intervene for HIV testing and treatment, and numerous couples-driven interventions exist (e.g. couples HIV testing and counseling, partner-provided HIV self-tests). However, it is unknown the extent to which there is homophily (like partnered with like) among household couples by HIV testing and…
Background The use of rapid tests for recent infection (RTRI) alongside CD4 as part of recent infection testing algorithm (RITA) has enabled identification of individuals who may have acquired HIV in the past 12 months (recent HIV infection). Measuring the risk for recent HIV infection is critical for effective public health interventions. We calculated the…
Background HIV incidence remains disproportionately high among men who have sex with men (MSM) globally and is increasing among MSM in India. To evaluate the feasibility of spatially tailored interventions to interrupt HIV transmission among Indian MSM, we explored the geospatial distribution of locations where MSM meet male sexual partners in Bhopal, India. Methods We…
Background Drug overdoses continue to devastate communities in Canada. British Columbia (BC), Canada’s westernmost province, has one of the highest drug-related mortality rates in the nation, with a fatal overdose rate double the national average (47.0 opioid deaths per 100,000 in BC; 21.1/100,000 in Canada). To better understand the breadth of the overdose crisis, this study evaluates…
Background Advanced HIV disease (AHD) among adults is defined as a CD4 count <200 cells/mm³ or a World Health Organization HIV clinical stage 3 or 4. Data regarding trends in AHD prevalence in sub-Saharan Africa are limited. Methods We analysed population-based HIV impact assessment (PHIA) household surveys from Eswatini, Lesotho, Malawi, Uganda and Zimbabwe, each…
Background Lesotho ranks second highest in national HIV prevalence globally. In April 2016, Lesotho was the first African country to adopt the World Health Organization (WHO) recommendation that all people with HIV (PWH) receive antiretroviral therapy (ART), regardless of clinical stage or CD4 cell count (CD4). Although CD4 is no longer used to guide treatment…
Background In recent years, the HIV epidemic in the Dominican Republic and surrounding regions in Latin America has disproportionately affected migrants, particularly those from Haiti and Venezuela. Migrants often face unique challenges along the HIV continuum of care that require tailored interventions. We conducted a study to understand the drivers of retention, attrition, and viral…
Background The HIV prevalence in Kisumu County, Western Kenya, is more than four times the national average. We estimated HIV incidence in a prospective cohort of adults with multiple sex partners in Kisumu County to identify HIV risk factors and evaluate the feasibility of future HIV vaccine and therapeutic clinical trials. Methods We enrolled male…