Abstracts from 2014 through the most recent CROI can be viewed in this searchable database once they have been presented at the conference. Abstract Contents: The searchable database includes abstract text as submitted by the authors prior to CROI. Study data might be updated during the presentation at CROI. Please refer to the electronic poster or webcast for updates. Searching the Abstract Database: Enter the criteria below and click the “Search” button. After the search has been entered, the results will appear below the search form.
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1277 Results
Background Antiretroviral therapy (ART) has significantly reduced AIDS-related deaths, yet death rates remain higher among people living with HIV (PLHIV) compared with individuals without HIV. This has been partly attributed to a higher risk of non-communicable diseases (NCDs) among PLHIV. Providing insights into NCDs’ contribution to the cause of death among PLHIV will guide priority…
Background The life expectancy of people living with HIV (PLWH) has improved notably since the advent of antiretroviral therapy (ART). However, studies have shown that persons aging with HIV are disproportionately impacted by comorbidities associated with aging, including osteoporosis. The gold standard tool for diagnosing osteoporosis is dual-energy X-ray absorptiometry (DXA), however its availability in…
Background We have previously shown in cross-sectional studies that COVID-19 infection was associated with arterial stiffness and increased oxidized LDL (oxLDL). In this study, we assess changes in these cardiovascular parameters after COVID infection in a group of individuals who have documented pre-COVID assessments. Having pre-COVID assessments has been a limitation of current studies. Methods…
Background PD1 antagonists are on the forefront of HIV curative strategies, but systemic treatment doses have led to limiting autoimmune toxicities. As such, there is interest in using subcutaneous low-dose delivery, but data are lacking. We recently completed a trial to evaluate low dose (10 mg or ~1.4 mg/kg) intra-lesional nivolumab in 6 males with…
Background Recent proteomic studies have documented that Long Covid in adults is characterized by a pro-inflammatory signature with thromboinflammation. However, if similar events happen also in children with Long Covid has never been investigated. Methods We performed proteomics analyses of blood plasma from pediatric patients younger than 19 years of age Long Covid and sex-…
Background Real world data continues to accumulate regarding the efficacy of long acting injectable (LAI) cabotegravir/rilpivirine (CAB/RPV); however, limited data exists regarding virologic outcomes in those returning to oral therapy after discontinuing LAI CAB/RPV. Methods Single-center cohort study at the UC San Diego Owen Clinic in those who initiated LAI CAB/RPV but discontinued treatment between…
Background Long-acting Cabotegravir and Rilpivirine (LA-CAB/RPV), approved in January 2021, is the first complete injectable regimen for virologically suppressed patients with HIV-1 without a history of resistance. The availability of LA-CAB/RPV offers a significant opportunity to expand the landscape of care for people with HIV. However, data on its implementation outside of early phase clinical…
Background Various distance to care (DTC) measures exist. It is unclear which most accurately predicts injection visit adherence for persons with HIV receiving long acting injectable (LAI) cabotegravir/rilpivirine (CAB/RPV). Objectives were to: i) identify which DTC measures were associated with injection visit no-shows (IVNS) and ii) compare the strength of association of each DTC measure…
Background The Ward 86 HIV Clinic in San Francisco serves publicly-insured people with HIV (PWH) living with multiple concomitant challenges. With the approval of long-acting (LA) cabotegravir/rilpivirine in 2021, Ward 86 started using LA antiretroviral therapy (ART) for those with adherence challenges to oral ART. More than 3.5 years into the program, we now report…
Background HIV-1 replicates in different body compartments and sub-compartments characterized by distinct compositions of small solutes and proteins. It is often assumed that virus proteins maintain the same conformation, function and sensitivity to inhibitors in different molecular environments, in vivo and in vitro. The protein albumin shows remarkable variability in concentration between the blood and…