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1277 Results
Background “Ending the HIV Epidemic in the US Initiative” strategies include supporting retention and re-engagement in care for people with HIV (PWH) (CDC EHE pillars). As part of a multidisciplinary initiative to enhance retention in care among PWH at our clinic, we hypothesized that we could identify demographic differences between patients who are and are…
Background Providing oral pre-exposure prophylaxis (PrEP) has not achieved population-level impact in southern Africa due to challenges reaching those with the highest risk of HIV-acquisition. We hypothesise that peer-led mobilisation into mobile sexual reproductive health (SRH) clinics will promote oral PrEP use amongst adolescents and young adults (AYA) at higher risk of HIV acquisition in…
Background In southern Africa the provision of pre-exposure prophylaxis (PrEP) has not translated into population-level impact due to the challenges of taking a daily oral pill. Injectable PrEP provides an opportunity to overcome this barrier. Using clinical process data from the Long-Acting PrEP Integrated with Sexual and Reproductive Health (LAPIS) trial, we explore changes in patterns…
Background PopART was a cluster randomized trial (CRT) designed to evaluate universal testing and treatment (UTT) strategies for HIV prevention. While CRTs are the gold standard for evaluating population-level effects, they can be subject to selection bias when those enrolled differ from the population of interest. PopART included two intervention arms: (A) combination prevention with…
Background Antiretroviral therapy (ART) improves clinical outcomes of people living with HIV (PLHIV) and achieving viral suppression through ART can prevent HIV transmission. We compared prevalence and correlates of unsuppressed viral load among PLHIV from two Tanzania HIV Impact Surveys (THISs). The first (survey 1 [S1]) was conducted from October 2016-August 2017; the second (survey…
Background Disengagement from antiretroviral treatment undermines HIV programme success. Current approaches targeting interventions at specific demographic groups miss most people out of care. Classifying patterns of engagement could use precision public health principles to identify unique care needs, and inform service development targeted at patients with similar experiences. Methods Using routine health data from the…
Background As cycling in and out of HIV care over time becomes the norm for people with HIV, most commencing antiretroviral therapy are now restarting rather than initiating treatment for the first time. Understanding patterns of engagement after a substantial treatment interruption could help to direct service implementation and choice of interventions for this crucial…
Background Long acting preexposure prophylaxis (PrEP) can address periods of partial adherence among individuals using oral PrEP. Using PrEP dispensing records, we determined the proportion of partially adherent men-who-have-sex-with-men (MSM) in Thailand who return within ten weeks and could benefit from cabotegravir as long-acting PrEP (CAB-LA). We then used a mathematical HIV transmission model to…
Background Women reported increased incidence of irregular menstruation (IM) during the COVID-19 (COVID) pandemic. No research has evaluated IM among women living with HIV (WWH) during the COVID pandemic, which is key to understanding reproductive health during co-infections. Methods From 2021-2023, cross-sectional data were collected from the Study of Treatment and Reproductive Outcomes (STAR) cohort…
Background Bacterial STIs are on the rise globally. Fast-dissolving dual-compartment (vaginal/rectal) inserts containing doxycycline (DOX) provide an alternate approach to STI prevention that can maximize local DOX concentrations while minimizing systemic distribution. Here, we performed preclinical studies to evaluate the pharmacokinetics (PK) and protective efficacy following vaginal administration of CONRAD-developed inserts containing DOX against vaginal C.…