Search Abstracts

Background Oral pre-exposure prophylaxis (PrEP) with emtricitabine/tenofovir (F/TDF) is highly effective in preventing HIV-1 acquisition, but uptake and adherence remain suboptimal. Long-acting injectable cabotegravir (CAB-LA) has shown high efficacy in trials, though real-world effectiveness data remain limited. We evaluated initial PrEP choices, reasons for selection, and associated factors in ImPrEP CAB Brasil, the first study to…

Background Since 1-Jan-2018, publicly-funded oral HIV Pre-Exposure Prophylaxis (PrEP) with generic emtricitabine-tenofovir disoproxil fumarate (FTC-TDF) has been available to key HIV populations in British Columbia (BC). We examined the renal safety of over 10,000 clients on FTC-TDF in BC’s population-level PrEP program. Methods Using data from BC’s PrEP program, we included clients with ≥1 FTC-TDF PrEP…

Background New HIV cases continue to rise in Latin America, especially among young men who have sex with men (MSM) and transgender women (TGW). Understanding long-term oral PrEP use is crucial for improving adherence and retention to services. This study explored PrEP use patterns over time in Brazil, identifying distinct trajectories and associated factors. Methods…

Background Health care transition (HCT) from pediatric/adolescent (P/A) to adult HIV care is a period of care continuum vulnerability. Outcomes of HIV HCT in the U.S. have only been studied up to 24 months post-transition and have not included the COVID pandemic. The University of Maryland STEP Program is a multi-disciplinary HCT program staffed by…

Background Latinx and Black transgender women (TGW) often face unique social, economic, and healthcare barriers that may limit their access to HIV prevention tools like PrEP. Research on racial disparities in PrEP use in these groups is limited. This study examined trends in PrEP uptake among Latinx and Black TGW in Los Angeles County (LAC)…

Background Adolescent girls and young women in southern Africa are disproportionately affected by HIV and sexual reproductive health (SRH) challenges. There is a need for more accessible and de-medicalized community spaces to offer person-centred HIV/SRH services for this key population. We aimed to assess the acceptability and feasibility of offering HIV/SRH services at hair salons…

Background The Dapivirine ring (DVR) is effective for HIV prevention among women at risk for HIV, and an alternative when other biomedical options may not be preferred or feasible. In the SEARCH Dynamic Choice Prevention (DCP) studies, participants at risk for HIV could choose between oral PrEP, PEP, CAB-LA, and the DVR. We describe characteristics…

Background Person-centered HIV care and prevention that provide low-barrier access and non-judgmental interactions may address poor outcomes among persons with alcohol use. Alcohol use is a risk factor for: a) non-retention in care and viremia among PWH, and b) non-retention in biomedical prevention and HIV acquisition among persons without HIV. We sought to determine if…

Background Only 68% of U.S. men-who-have-sex-with-men (MSM) living with HIV have achieved virologic suppression (VS), sufficiently low to compromise Ending the HIV Epidemic goals. Objective monitoring of antiretroviral therapy (ART) adherence via drug-level testing can inform interventions. A rapid, low-cost urine point-of-care (POC) tenofovir (TFV) assay has been developed by our group as an objective…

Background The SEARCH dynamic choice HIV prevention (DCP) intervention, including structured choice of biomedical prevention modality (oral PrEP, PEP, Cab-LA) with option to switch over time, increased time covered by biomedical prevention and reduced HIV incidence among men and women in randomized trials in Kenya and Uganda. We use HIV Synthesis, an existing individual-based HIV…