Abstracts from 2014 through the most recent CROI can be viewed in this searchable database once they have been presented at the conference. Abstract Contents: The searchable database includes abstract text as submitted by the authors prior to CROI. Study data might be updated during the presentation at CROI. Please refer to the electronic poster or webcast for updates. Searching the Abstract Database: Enter the criteria below and click the “Search” button. After the search has been entered, the results will appear below the search form.
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1277 Results
Background Background: Switching to DTG/3TC (DOV) or BIC/FTC/TAF (BIK) in the PASO-DOBLE trial (ClinicalTrials.gov NCT04884139) showed noninferior efficacy of DOV vs. BIK and weight gain in both groups, which was significantly greater for BIK at 48 weeks. We aimed to know how switching to DOV or BIK affects body composition and whether there are differences…
Background MK-8527 is a novel nucleoside reverse transcriptase translocation inhibitor (NRTTI) under clinical development as an oral monthly antiretroviral agent for prevention of HIV‑1 infection. MK‑8527 is phosphorylated intracellularly to the pharmacologically active triphosphate form, MK-8527-TP. Clinical and nonhuman primate data were incorporated into an assessment of the pharmacokinetic/pharmacodynamic (PK/PD) relationship for MK-8527-TP to inform…
Background There is interest in metformin as a drug to delay aging in the general population. This is the first trial to evaluate the impact of metformin on biological aging measured by epigenetic clocks with prognostic value in PWH. Methods Phase II randomized, double-blind, pilot clinical trial comparing metfomin 850 mg BID vs placebo. Main inclusion…
Background Long COVID (LC) can trigger dysautonomia or dysfunction of the autonomic nervous system (ANS) similar to some autoimmune diseases. Dysautonomia has been related with autoantibodies produced by activated non-specific B-cell clones that may interfere with the ANS normal function. Our objective was to analyze alterations in the humoral immunity with a specific focus on…
Background SARS-CoV-2 (SCV2) RNA and antigens can be found in several tissues many months after infection, but whether SCV2 persistence causes Long COVID (LC) is unproven. The scant data in favor of causation has related persistent SCV2 to non-specific LC definitions. It is unknown whether persistent SCV2 is associated with all, or only some, of…
Background We previously demonstrated increased T cell activation across many tissue types in people months to years following SARS-CoV-2 infection compared to participants imaged prior to the COVID-19 pandemic using a novel PET imaging tracer of T cell activation ([18F]F-AraG). The relationships between persistent whole-body T cell activation and various Long COVID (LC) clinical phenotypes,…
Background Cryptococcal meningitis (CM) remains a frequent opportunistic infection among individuals with advanced HIV disease, causing significant morbidity and mortality. CM incidence has fallen in high HIV-prevalence settings with expansion of ART. Few countries other than South Africa collect reliable data on CM; robust longitudinal data describing the impact of HIV programme interventions and changes…
Background Integrase strand transfer inhibitors (INSTI), such as dolutegravir and bictegravir, may be associated with neuropsychiatric symptoms in people living with HIV. Due to drug-drug interactions during co-treatment with rifampicin-based TB treatment, the dose of the INSTI is often doubled. However, the neuropsychiatric outcomes in people with TB/HIV during bictegravir double-dosing has not been evaluated. …
Background Treatment with long-acting antiretroviral therapy (LA ART) with cabotegravir/rilpivirine (CAB/RPV) +/- lenacapavir (LEN) holds promise to achieve viral suppression (VS) in people with HIV (PWH) for whom oral ART fails. Although supported in certain scenarios by guidelines, scaling this approach in viremic PWH has lagged Methods We performed a retrospective review of PWH cared for…
Background The effect of metformin on reducing symptom duration among low-risk, outpatient adults with mild to moderate coronavirus disease 2019 (COVID-19) has not been studied. Our objective was to test metformin compared to placebo for symptom resolution during acute infection with SARS-CoV-2. Methods The ACTIV-6 platform clinical trial evaluated repurposed medications for mild to moderate…