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1277 Results
Background The risk of progression from Mycobacterium tuberculosis (Mtb) infection to active TB disease is estimated to be up to 20 times higher in people living with HIV (PLWH), with fatality rates of 16 – 35%. We have previously shown that blood transcriptional biomarkers can predict risk of TB progression in PLWH. We use transcriptional…
Background Data on child development following in utero antiretroviral (ARV) exposure suggest increased risk of delay in language skills, although most studies to date are among women living with HIV and their infants who have exposure to both ARVs and HIV. We assessed the relationship between prenatal PrEP exposure and language development at 60 months…
Background Dolutegravir (DTG) is approved for treatment of HIV-1 in adults and pediatric patients ≥4 weeks and ≥3 kg. We previously reported the pharmacokinetics (PK) and safety of two single doses of DTG (0.5 mg/kg) given with standard of care antiretrovirals in the first 13 days of life. Here, we describe preliminary PK and safety…
Background Recent studies have reported on children born with HIV and treated from the first 48 hours of life who achieved undetectable HIV-1 DNA after 2 years of life. In this study, we report five children who started ART within 4 months of age in Sub-Saharan Africa (SSA), who achieved sustained undetectable HIV-1 DNA after 2…
Background Long-acting cabotegravir (CAB-LA) plus long-acting rilpivirine (RPV-LA) are approved for maintenance of viral suppression in adults and adolescents >35kg with HIV-1 infection. IMPAACT 2036 (CRAYON) is a Phase I/II, multi-center, open-label, non-comparative study to evaluate safety, tolerability, acceptability and pharmacokinetics (PK) of oral (PO) and intramuscular (IM) CAB-LA+RPV-LA in children 2-<12 years, living with HIV-1.…
Background Men who have sex with men (MSM), a group with high HIV incidence, may seek sexual partners through virtual (geosocial or dating apps) or in-person (bars or clubs) venues. Both types of venues facilitate partnerships among MSM and increase transmission of sexually transmitted infections and HIV. This analysis assessed if virtual and in-person sampling…
Background Despite advances in the potency of antiretroviral (ARV) medications to treat and prevent transmission of human immunodeficiency virus (HIV), the most common regimens in the United States (U.S.) necessitate daily pill-taking. While there is consensus that social determinants of health (SDoH) hinder adherence, SDoH are typically measured and intervened upon at the individual level.…
Background First-time testers are often overlooked by conventional HIV services, yet they play a critical role in achieving the goal of ensuring all at-risk individuals know their status. Online platforms—such as TikTok and LINE—offer accessible, anonymous, and engaging options to reach these groups, especially at-risk adolescents and young adults. By leveraging digital channels, innovative HIV…
Background Integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) has been associated with disproportionate weight gain among people with HIV (PWH), primarily in treatment-naïve populations. Few studies have explored weight and cardiometabolic outcomes beyond two years and even fewer have examined effects on major adverse cardiovascular events (MACE). Methods Using target trial emulation, we estimated…
Background Since May 2022, over 27,000 cases of monkeypox (MPOX) have been reported in Europe where the disease is not endemic. In the Democratic Republic of Congo (DRC), this disease has become a public health emergency, with 19,667 suspected cases and 575 deaths reported in 2024. Monkeypox virus (MPXV) represents a diagnostic challenge due to…