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1277 Results
Background Approximately 13% of people with HIV are unaware of their HIV status. Distribution of HIV self-tests (HIVSTs) to populations most affected by HIV increases awareness of infection, and may facilitate initiation of treatment. Previous work has described HIVST distribution programs, but not confirmation of diagnosis or engagement in antiretroviral therapy (ART). Methods A national…
Background Aim is to evaluate the changes in antimicrobial consumption of ceftriaxone, benzylpenicillin and doxycycline for the treatment of bacterial sexually transmitted infections (bSTIs), after the prescription of doxycycline post-exposure prophylaxis (DoxyPEP) among men who have sex with men (MSM). Methods Retrospective study of MSM in care for HIV or HIV pre-exposure prophylaxis (PrEP) at…
Background Clinical trials have shown high efficacy of doxycycline as STI preventive strategy, but real-world data are limited. We aimed to assess the impact of DoxyPEP on Chlamydia trachomatis (CT), Neisseria gonorrhoeae(NG) and syphilis (SPL) incidence in a high-risk MSM cohort in a real-world setting. Methods PrEP users at our clinic, meeting high STI risk…
Background Despite significant progress in HIV treatment, maintaining patient engagement in care remains a critical challenge. While UNAIDS aims to achieve the “95-95-95” targets by 2030, many people living with HIV (PLHIV), particularly in sub-Saharan Africa, tend to discontinue care within two years. Current one-size-fits-all interventions often lack efficient targeting, and resources could be better…
Background Despite studies demonstrating an increase in myocardial steatotic burden in adults with HIV on antiretroviral therapy (ART), no studies have evaluated this phenomenon in youth with perinatally-acquired HIV (YPHIV). Methods The Cape Town Adolescent Antiretroviral Cohort (CTAAC)-Heart study enrolled youth to assess myocardial fibrosis and inflammation using cardiovascular magnetic resonance (CMR). A magnetic resonance…
Background HIV-1 Exceptional Elite Controllers (EEC) maintain undetectable viremia and halt disease progression more than 20 years after infection in the absence of treatment and may be considered as functionally cured. However, loss of control in these individuals is unknown. In this study we performed a detailed, longitudinal characterisation of the HIV-1 reservoir, viral evolution…
Background The human gut has a high burden of HIV, but little is known about the phenotypes of HIV reservoir cells at this site or the influence of the local microenvironment. Here, we used standard and 40-parameter multiplexed ion beam imaging by time of flight (MIBI-TOF) microscopy to study the HIV reservoir and their associated environments…
Background Intra-host evolution reflects a general mechanism for the continued emergence of novel highly divergent SARS-CoV-2 variants. The intra-host evolution of SARS-CoV-2 was investigated with the aim of assessing conditions associated with the acquisition of new viral mutations through the sequencing of viral genomes. Methods 58 cases of COVID-19 with 2 or more longitudinally positive…
I will overview the state of the art in HIV prevention efficacy trial design and articulate lessons learned from recently conducted trials.
This case-based session will address the most common cause of liver disease namely metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-associated liver disease (ALD), and the overlapping entity MetALD. The audience will become familiar with the new nomenclature, epidemiology, clinical diagnosis, and risk-stratification using non-invasive tests. In addition, practical approaches to MASLD treatment including newly approved…