Abstracts from 2014 through the most recent CROI can be viewed in this searchable database once they have been presented at the conference. Abstract Contents: The searchable database includes abstract text as submitted by the authors prior to CROI. Study data might be updated during the presentation at CROI. Please refer to the electronic poster or webcast for updates. Searching the Abstract Database: Enter the criteria below and click the “Search” button. After the search has been entered, the results will appear below the search form.

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Search Results

1277 Results

148 – Bispecific Antibody VRC07/PGT121 Protects Against High-Dose Intravenous SHIV-BG505 Challenge

Background Non-human primate (NHP) and human clinical studies highlight the utility of broadly neutralizing antibodies (bNAbs) for immunoprophylaxis against HIV-1. Passively delivered bNAbs protect against viral strains susceptible to antibody-mediated neutralization.  To protect against HIV-1 strains resistant to individual antibodies, endeavors to improve bNAb breadth are required.  A key strategy to enhance the neutralization breadth…

145 – Lymph Node HIV-Specific CD8 T Cells of HIV Controllers Harbour a Specific Transcriptomic Signature

Background Depletion studies in non-human primates demonstrated the crucial role of CD8 T cells in controlling SIV replication. However, the precise mechanisms underlying the control of HIV replication remain elusive. Lymph nodes (LN) are a primary site of HIV replication, and studying the CD8 T cell response at this level may provide additional insights. Methods We…

142 – Profiling Therapeutic Vaccine-Driven HIV-Specific CD8 T Cells With Single-Cell TCR Sequencing Assays

Background Generating robust virus-specific CD8+ T cell responses is the major objective of most HIV therapeutic vaccines. However, standard T cell assays fail to distinguish whether vaccine-expanded T cell populations are boosted pre-existing responses and/or newly-recruited clonotypes. Here, we utilized two single cell T cell receptor (TCR) sequencing approaches to characterize CD8+ T cell clonotypes…

143 – Efficacy of Bivalent Versus Monovalent COVID-19 Vaccines Among People With HIV, Ubuntu Trial, 2022-24

Background Prospective trials have not previously compared the efficacy of boosting with the ancestral/monovalent mRNA vaccine (WA-1) versus a bivalent ancestral plus BA.4/BA.5-targeted vaccine in African countries, with high HIV and SARS-CoV-2 seroprevalence. Methods The second phase of CoVPN 3008 (Ubuntu trial) was a double-blind randomized trial in 7 countries, among people with HIV (PWH)…

104 – HIV GAG x CD3 Soluble TCR Bispecific Reduces the Active HIV Reservoir in a Phase I/II Trial

Background ImmTAV® are soluble bispecific T cell engagers that kill virus-infected cells presenting extremely low target peptide-HLA levels. IMC-M113V (GAGxCD3) is the first HIV ImmTAV in the clinic; a single dose study demonstrated safety and biological activity in antiretroviral therapy (ART)-suppressed PLWH. We investigated the effect of multiple ascending doses of IMC-M113V on HIV reservoir…

1307 – Machine Learning to Predict Persons With HIV at Risk of Falling Out of Care

Background Effective antiretroviral therapy to maintain durable viral suppression is key to ending the HIV epidemic in the United States. We evaluated the ability of machine learning (ML) algorithms to predict people with HIV (PWH) who are at risk of falling out of care. Methods This was a retrospective study among all PWH in San…

1308 – An AI-Powered Preventive Intervention for Stigma and Suicidal Ideation in HIV Self-Management

Background Self-harm and suicidal ideation are significant health concerns among people with or vulnerable to HIV (PWH), who frequently experience stigma and related mental health challenges such as stress, anxiety, and depression. The AI-powered MARVIN chatbot provides HIV self-management-related knowledge and assists with medication adherence (antiretroviral therapy and pre-exposure prophylaxis). It also provides a safe…

1312 – Impact Analysis and Machine Learning Forecasts of HIV Viral Load Suppression in 21 African Countries

Background Viral load suppression (VLS) is crucial for controlling HIV transmission and improving health outcomes in people living with HIV. While PEPFAR-supported programs have made substantial progress in improving VLS, innovative approaches are needed to sustain and enhance VLS in resource-limited settings. This analysis integrates machine learning and the difference-in-difference (DiD) method to forecast future…

1282 – The Actual Need for DoxyPEP Might Not Be as Large as Expected

Background DoxyPEP proved to be effective in preventing bacterial sexually transmitted infections (STIs) and the Centers for Diseases Control and Prevention (CDC) recommended it in men who have sex with men (MSM) and transgender women (TGW) who have had at least one infection in the previous 12 months. However, the risk of antibiotic overuse and…

1288 – DoxyPrEP Impact on the Microbiome of Men Who Have Sex With Men and Transgender Women on HIV PrEP

Background Doxycycline pre-exposure prophylaxis (doxyPrEP) has shown potential in preventing bacterial sexually transmitted infections (STIs) in gay, bisexual and other men who have sex with men (GBM). However, its impact on the microbiome is unknown. This study assessed rectal microbiome changes over 48 weeks in participants on HIV PrEP enrolled in a doxyPrEP trial. Methods…