The deadline for general abstract and scholarship submissions to the hybrid 2022 Conference on Retroviruses and Opportunistic Infections (CROI) has now passed. Dispositions will be sent by email on December 10, 2021. Late-breaking abstract submission opens December 13, with a deadline of January 5, 2022. Studies that include data analyzed after general abstract submission and meet a high threshold of scientific merit are suitable for late-breaking abstract submission.