The CROI Scientific Program Committee is carefully monitoring the COVID-19 pandemic and appropriate safety measures for in-person attendance. The in-person component will be hosted at the Colorado Convention Center in Denver, Colorado, USA. As the conference opening date approaches, this section will be updated with the latest travel and specific safety requirements for in-person attendees (eg, vaccination, masks, and social distancing). Please check the CDC guidance, as we will be primarily following the instructions set by CDC. Please note that the information provided is subject to change, as it will be updated as the pandemic evolves.