In this session, Drs. Pedro Cahn and Jenny Hoy will present cases to an expert faculty panel from around the world to highlight cutting-edge issues in the care of people with HIV. Topics will include the management of weight gain in the setting of ART, the approach to cardiovascular events in people with HIV, whether people who are elite controllers should be treated with ART, and ART considerations for people with drug-resistant HIV and adherence challenges. This stimulating interactive session will illustrate the current evidence-based approaches to managing people with HIV from different parts of the world.