SEATTLE, WASHINGTON

February 13–16, 2017

Conference Dates and Location: 
February 23-26, 2015 | Seattle, Washington
Abstract Number: 
1019LB

HIV Transmission in Male Serodiscordant Couples in Australia, Thailand and Brazil

Author(s): 

Andrew E. Grulich1, Benjamin R. Bavinton1, Fengyi Jin1, Garrett Prestage1, Iryna B. Zablotska1, Beatriz Grinsztejn2, Nittaya Phanuphak3, Richard Moore4, Kersten K. Koelsch1
1 Kirby Institute, University of New South Wales, Sydney, NSW, Australia. 2 Instituto de Pesquisa Clínica Evandro Chagas, Rio de Janiero, Rio de Janiero, Brazil. 3 Thai Red Cross AIDS Research Centre, Bangkok, Thailand. 4 Northside Clinic, Melbourne, VIC, Australia.

Abstract Body: 

Background: Numerous prospective studies have demonstrated that HIV transmission is greatly reduced in heterosexual HIV serodiscordant couples when the HIV-positive partner (HPP) is receiving combination anti-retroviral therapy (cART) with undetectable viral load (UVL). Comparable data in homosexual male serodiscordant couples (HM-SDC) are extremely limited. We report a pre-specified interim analysis of the relationship between UVL and HIV transmission in the Opposites Attract observational cohort study of HM-SDC in Australia, Bangkok and Rio de Janeiro.

Methods: HM-SDC reporting regular anal intercourse with each other were recruited through clinical sites. Detailed information on sexual risk behaviours was collected at each visit from the HIV-negative partner (HNP). HNPs were tested at baseline and follow-up for HIV antibodies and STIs (sexually transmitted infections), and HPPs for HIV viral load and STIs. Incidence rates were calculated per couple-year of follow-up (CYFU) using person-year methods, and stratified by whether different forms of condomless anal intercourse (CLAI) were reported. UVL was defined as <200 copies/mL. One-sided confidence intervals (CI) were calculated using the exact Poisson method. Linked HIV transmission in couples was defined by phylogenetic analysis.

Results: By December 2014, 234 HM-SDC were enrolled: 135 from Australia, 52 from Bangkok and 47 from Rio de Janeiro. There were a total of 150.0 CYFU in 152 couples with at least one follow-up visit of whom 65 (42.8%) were in a non-monogamous relationship. At baseline, 84.2% of HPPs were on cART and in total 82.9% had UVL. STI prevalence was 11.2% in HPPs and 6.6% in HNPs. There were 90.8 CYFU in periods where CLAI was reported with a total of 5,905 acts of CLAI in 88 couples. There were no linked HIV transmissions. The upper limit of the 95% CI of the transmission rate was 4.06/100 CYFU for periods in which CLAI was reported, and 6.46/100 CYFU for periods in which receptive CLAI was reported.

Conclusions: There were no linked HIV transmissions in 150 CYFU in these HM-SDC, despite close to 6,000 acts of CLAI. The upper confidence limit of the transmission rate during follow-up in periods during which CLAI was occurring was 4.06/100 CYFU. These data add to emerging evidence that the rate of HIV transmission in HM-SDC is very low when the HIV-positive partner is on ART. Further follow-up of a larger sample size is required to accurately delineate any residual risk.

  Linked transmissions (n) Couple-years of follow up (CYFU) No. of CLAI acts Incidence rate per 100 CYFU
(95% CI)
Overall 0 149.96 5905 0 (0-2.46)
Any CLAI 0 90.83 5905 0 (0-4.06)
Insertive CLAI 0 77.87 3569 0 (0-4.74)
Receptive CLAI 0 57.08 2337 0 (0-6.46)
Any CLAI when VL <200 copies 0 88.59 5656 0 (0-4.16)
Any CLAI when VL >200 copies 0 2.00 237 0 (0-184)

 

Session Number: 
P-W3
Session Title: 
Risk Factors for Transmission in MSM
Presenting Author: 
Grulich, Andrew
Presenter Institution: 
University of New South Wales
Poster: