WASHINGTON STATE CONVENTION CENTER

Seattle, Washington
March 4–7, 2019

 

CROI 2019 Categories and Definitions

Abstract categories may be modified from year to year.

Notes on category selection:

  • All studies of infants, children, or adolescents should be submitted to Category (Q) Pediatrics and Adolescents
  • All resistance studies and trials should be submitted to category (I) HIV Drug Resistance
  • All studies of Hepatitis (including A, B, C, and E in monoinfection or HIV coinfection) should be submitted to category (K) Hepatitis Viruses and Liver Complications
  • All studies of the technical performance of HIV diagnostic tests should be submitted to category (J) HIV Diagnostics. Studies applying new HIV diagnostics in populations should be submitted to category (S) Testing

Category

Definition

Basic Science

A

Virology

Studies of viral and host factors, including studies of replication in vitro, host restriction factors, viral life cycle, entry, tropism, and early and late viral phenotypes

B

Pathogenesis: Human Studies and Animal Models

Studies of factors influencing disease outcome in humans and animal models, including HIV-host interactions, immune activation, host cell targets, cell compartments, genotype (viral and host) and disease, immune restoration, and mucosal factors

C

HIV-Associated Tumor Viruses

Studies on basic science relating to HIV-associated tumor viruses (eg, KSHV, EBV, HPV, hepatitis B, Merkel cell polyoma virus) including viral life cycle, viral replication and transcription, viral-host interactions, pathogenesis and oncogenesis, and viral immunology

D

Host Immune Responses to Infection, Vaccines, and Immunotherapy

Studies of B- and T-cell responses to viral infection, vaccines, and immune modulation (eg, cytokine interventions)

E

HIV Reservoirs, Latency, and All Curative Strategies Including Therapeutic Vaccines and Gene Therapy

Studies of all aspects, including human and animal studies, related to these topics

F

Neuropathogenesis and Neurologic Complications

Studies of all aspects of neuropathogenesis, including neuroimmunity, neurodegeneration, virology of the CNS compartment (HIV entry, tropism, evolution, reservoir), CNS complications of systemic HIV infection including neurocognitive dysfunction, and associated factors/responses, cerebrovascular complications (in conjunction with the Cardiovascular Complications clinical group), and biomarkers (including neuroimaging)

Clinical

G

Clinical Pharmacology

All studies of the pharmacokinetics and pharmacodynamics (PK/PD) in animal models and humans, including studies of drug ADME, novel dosing regimens, drug interactions, and experimental/clinical therapeutics. Includes pharmacologic modeling

H

Antiretroviral Therapy: Pre-Clinical Data, Randomized Trials, Efficacy and Effectiveness Studies

Studies of antiretroviral agents and combinations (all phases, including pre-clinical data), including new agents, combinations, randomized trials and observational and cohort studies where the focus is on antiretroviral therapy and antiretroviral treatment strategies

I

HIV Drug Resistance

Studies of molecular mechanisms, pathogenesis, clinical implications, epidemiology, and resistance diagnostics

J

HIV Diagnostics

Studies of HIV diagnostic tests and their technical performance characteristics. Studies applying new HIV diagnostics in populations should be submitted to category S. Testing. Studies of new technologies related to HIV drug resistance, complications, TB, other opportunistic infections, hepatitis, or malignancies should be submitted to those specific categories

K

Hepatitis Viruses and Liver Complications

Studies of diagnostics, epidemiology, pathogenesis, and therapy for Hepatitis viruses and liver complications

L

AIDS-Related Malignancies

Studies on the epidemiology, pathobiology, prognostic biomarkers, incidence, treatment, gynecologic malignancies, HPV screening, and prevention approaches for malignancies or premalignant lesions in patients with HIV infection

M

Cardiovascular Complications of HIV Infection and Antiretroviral Therapy

Includes coronary, cardiac, and cerebrovascular complications, lipids, and peripheral vascular atheromatous disease

N

Other Complications of HIV Infection and Antiretroviral Therapy

Studies of renal, bone, metabolic, and other complications (excluding neurologic or liver complications). Neurologic complications should go to category (E) Neuropathogenesis and CNS HIV Complications and liver complications should go to (K) Hepatitis Viruses and Liver Complications

O

Tuberculosis and Other Opportunistic Infections

Basic and clinical examination of bacterial, fungal, parasitic, and non-hepatitis viral infections

P

Maternal and Fetal HIV

Studies of maternal-fetal transmission (risks, mechanisms, approaches to prevention and treatment during pregnancy and breast feeding) and early infant diagnosis

Q

Pediatrics and Adolescents

Studies of HIV in infants, children, and adolescents, including HIV-exposed, uninfected children

Epidemiology/Public Health

R

Epidemiology

Risk factors for acquisition/transmission, cohort studies, incidence/prevalence, morbidity/mortality, surveillance, transmission clusters, phylogenetics, and molecular epidemiology

S

Testing

Studies applying new HIV diagnostics in populations (eg community-, partner-, and self-testing). Includes studies evaluating tests (such as incidence algorithms), new testing approaches, scale-up of HIV testing, and descriptive epidemiology of testing results. Studies of HIV diagnostic tests and their technical performance characteristics should be submitted to category (J) HIV Diagnostics

T

Prevention Interventions

Preclinical and clinical studies of microbicides, pre- and post-exposure prophylaxis, treatment as prevention, medical male circumcision, and other prevention interventions. Implementation of prevention strategies for HIV uninfected populations, and studies in which HIV incidence is the primary outcome

U

Contraception, Sexually Transmitted Infections, and Reproductive Health

Studies of the impact of contraceptive methods on HIV infection or disease, sexual health, sexually transmitted infections, and treatment of pregnant women for conditions other than pregnancy. Does not include studies on HIV epidemiology, prevention, and treatment for women; these should be included in their respective categories

V

Implementation and Scale-Up of Treatment and Care

Including cascades, financing of care, and population-level impact of treatment and care on health outcomes of persons living with HIV

W

Population and Cost Modeling

Includes research on demography, population impact, modeling and cost-effectiveness. Does not include pharmacologic modeling (submit to Clinical Pharmacology) or basic science modeling (submit to the appropriate basic science category)